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KMID : 0351619650060010028
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Kyungpook Medical Journal
1965 Volume.6 No. 1 p.28 ~ p.33
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The Study of The Pharmacological Action of the 2.4.5-Trichlorophenoxyetylene Pyridinium Bromide TCPB on the Experimental Animals/
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Abstract
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Author had presented the first report on the general pharmacological actions and the marked hypotensive action of TCPB. This present study was carried out to observe the autonomic gaglionic blocking action and to determine the mechanism of the hypotensive action of TCPB.
Results were as follows:
1) The marked hypotensive action was observed in the rabbit with 0.5-1.0 mg/kg of TCPB.
2) The Contractile response of the nictating membrane, was inhibited with 5mg/kg. in the cat
3) 1.0mg/kg of TCPB did not block the hypertensive effect obtained by the intravenous injection of 0.05mg/kg of Noradrenaline.
4) TCPB antagonized the hypertensive effect of the ephedrine.
5) TCPB revealed the hypotensive action after the vagotomy in the rabbit.
6) When the hypotension developed with 10mg/kg of TCPB, the stimulation of vagus nerve did not reveal the hypotensive response.
7) The hypotensive action of TCPB appeared after the premedication with the atropine in the rabbit.
8) When the hypotension developed ? TCPB, hypertensive response was not appeared even with the occulsion of the carotid artery.
9) TCPB inhibited the hypertensive response of the nicotine.
10) Chlorophenamine did not inhibit the hypotensive action of TCPB.
11) These effects mentioned were seemed due to the autonomic ganglionic blocking action.
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